Genomic sequence analyses of classical and non-classical lamprey progesterone receptor genes and the inference of homologous gene evolution in metazoans

Table 2 Motif frequency from lamprey progesterone receptor protein sequences

Motif group	Motif name	mPRβ	mPRγ	mPRδ	mPRε	PGRMC1	PGRMC2	neudesin	neuferricin	nPR
Acidophilic Ser/Thr kinase	Casein kinase 1	0	0	0	0	1^a	0	0	0	0
	Casein kinase 2	0	0	0	0	2	1^a	0	0	0
	GSK3	2	0	0	0	0	0	0	0	0
Basophilic Ser/Thr kinase	Akt kinase	0	0	0	0	0	1	0	1	1
	AMP kinase	1^a	0	2	0	0	0	0	0	1
	Calmodulin dependent kinase 2	0	0	0	0	0	0	0	1	0
	Clk2 kinase	1	0	0	1	0	0	0	0	0
	PKC_δ	1	1	1	0	0	0	0	0	0
	PKC_ε	0	0	0	0	0	0	1^a	0	1
	PKC_ζ	2	0	0	1	0	0	0	0	0
	PKC_μ	0	0	1	0	0	0	0	0	1
DNA damage kinase	DNA PK	0	0	0	0	0	2	1^a	0	2
DNA damage kinase	ATM kinase	0	0	1	0	0	0	1^a	0	1^a
Kinase binding site	Erk1 binding	1^a	2 (1^a)	2	0	0	0	0	0	0
	Erk D-domain	2	0	0	1	0	1	1	2	0
	PDK1 binding	1	1	0	2 (1^a)	0	0	0	1	2
Lipid binding	PIP₃ binding PH	0	2	0	0	0	0	0	0	0
Phospho-Ser/Thr binding	14-3-3 mode 1	0	1	0	0	0	0	0	0	1
Proline-dependent Ser/Thr kinase	Erk1 kinase	0	0	0	0	0	0	0	0	1^a
Src homology 2 (SH2)	Abl SH2	0	1	0	0	0	0	0	0	0
	Grb2 SH2	0	0	0	1	0	0	0	0	0
	Itk SH2	0	0	0	0	0	0	0	0	1
	PLCγ C-terminal SH2	0	1	0	0	0	0	0	0	0
	Shc SH2	0	0	0	0	0	1	0	0	1
	SHIP SH2	0	0	0	0	0	1	0	0	0
Src homology 3 (SH3)	Cbl-associated protein C-SH3	1^a	0	0	0	0	0	0	0	0
	Grb2 SH3	0	0	0	0	0	0	0	1	0
	Itk SH3	1	0	0	0	0	0	0	0	0
	p85 SH3 mode 2	1	0	0	0	0	0	0	0	0
Tyrosine kinase	Abl kinase	0	0	0	0	1	0	0	0	0
	Insulin receptor kinase	1	0	0	0	0	0	0	0	0
	Lck kinase	0	0	0	0	1	1	0	0	1
	Src kinase	0	0	0	0	0	1	0	0	1

Protein motifs were predicted using the Scansite cell signaling interactions prediction “MotifScan” module (https://scansite4.mit.edu/4.0/#scanProtein) under medium stringency setting. ^aMotifs that were also predicted under high stringency setting. Motif sequences are listed in Additional file 4

ISSN: 2730-7182