Fig. 5

Comparative domain organization of PD causing proteins and their interacting residues. a Comparative organization of key functional domains and motifs of human UCHL1, SNCA and PARKIN. Protein lengths are drawn approximately to scale. Domains and motifs are color coded. b Docked complex and hydrogen bonds between human UCHL1 (2ETL) and human PARKIN proteins. Interaction structures are color coded. Total 15 interacting residues are identified, subset of them are displayed on the docked complex. UCHL1 interaction residues are shown in black color, whereas PARKIN residues are shown in red color. c Docked complex and hydrogen bonds between human UCHL1 (2ETL) and human SNCA proteins. Interaction structures are color coded. Total 5 interacting residues are identified and all of them are displayed on the docked complex. UCHL1 interaction residues are shown in black color whereas SNCA residues are shown in red color