Figure 3

Phylogenetic analysis of Pleurobrachia pileus MHCII sequences. Amino-acid sequences were analysed using the Maximum likelihood (ML) method. Numbers associated with the branches are ML bootstrap values (1000 replicates). Sequences from Pleurobrachia pileus are indicated in bold font and green colour. The MHCIIa clade is indicated in blue and the MHCIIb clade in purple. The letter between parentheses after the name of mouse genes of the MHCa clade indicate whether the gene is expressed in non-muscle cells (n) or in smooth muscle cells (s). Abbreviations for species names: Aae: Aedes aegypti ; Aqu: Amphimedon queenslandica; Asu: Ascaris suum; Cow: Capsaspora owczarzaki; Ddi: Dictyostelium discoideum ; Dme: Drosophila melanogaster; Hma: Hydra magnipapillata; Lgi: Lottia gigantea; Lpe: Loligo pealei; Mbr: Monosiga brevicollis; Mmu: Mus musculus; Nve: Nematostella vectensis; Ppi: Pleurobrachia pileus; Sar: Sphaeroforma arctica; Sro: Salpingoeca rosetta; Tad: Trichoplax adhaerens.