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Table 3 Ciona genes related to Human GPCR associated diseases.

From: The repertoire of G protein-coupled receptors in the sea squirt Ciona intestinalis

Human Disease Category Human GPCRs Candidate CionaGPCRs
Autosomal Dominant Hypocalcemia (ADH), Sporadic Hypoparathyroidism, Familial Hypoparathyroidism CaSR ci0100130340
Hypogonadotropic hypogonadism (HH) GNRHR ci0100133065
   ci0100134571
   ci0100152622
   ci0100153146
Nephrogenic diabetes insipidus (NDI) AVPR2 ci0100139176
Precocious puberty, male Pseudohermaphroditism LHCGR ci0100133821
Chondrodysplasia, multi-organ disorders, metabolic disorders PTHR1 ci0100139945
   ci0100151327
Sporadic basal cell carcinoma, Somatic mutation SMOH ci0100150930
Hypertension, Asthma ADRB2 ci0100130320
   ci0100137803
  1. The list of top hits among Ciona genes in a BLASTP search against human disease related GPCRs. The list is based on an E-value cut-off of ≤1e-20 and further verification by phylogenetic analysis. The Ciona matches were checked for their alignment with the human proteins over the length of the TM region. Swiss-Prot identifiers are reported for the human GPCRs.