Effect of temperature and glia in brain size enlargement and origin of allometric body-brain size scaling in vertebrates
© Yu et al.; licensee BioMed Central Ltd. 2014
Received: 2 May 2014
Accepted: 29 July 2014
Published: 3 October 2014
Brain signaling requires energy. The cost of maintaining and supporting energetically demanding neurons is the key constraint on brain size. The dramatic increase in brain size among mammals and birds cannot be understood without solving this conundrum: larger brains, with more neurons, consume more energy.
Here we examined the intrinsic relationships between metabolism, body-brain size ratios and neuronal densities of both endothermic and ectothermic animals. We formulated a general model to elucidate the key factors that correlate with brain enlargement, and the origin of allometric body-brain size scaling. This framework identified temperature as a critical factor in brain enlargement via temperature-regulated changes in metabolism. Our framework predicts that ectothermic animals living in tropical climates should have brain sizes that are several times larger than those of ectothermic animals living in cold climates. This prediction was confirmed by data from experiments in fish brains. Our framework also suggests that a rapid increase in the number of less energy-demanding glial cells may be another important factor contributing to the ten-fold increase in the brain sizes of endotherms compared with ectotherms.
This study thus provides a quantitative theory that predicts the brain sizes of all the major types of animals and quantifies the contributions of temperature-dependent metabolism, body size and neuronal density.
Brain size is a traditional metric of intelligence. Species with larger brain-body size ratios are often associated with greater intelligence, better tool-making skills, more social interactions, and other enhanced characteristics . Although many correlations between large brains and complex behavioral measures have been posited over the past century, the driving forces and key factors underlying the development of larger brain-body size ratios in mammals and birds are still an open issue -. The evolution of large brains in mammals and birds coincided with the development of endothermy  at the end of the Triassic period (~200 million years ago)  during which time the first mammals evolved from therapsids (i.e., the mammal-like reptiles) and has continued in primates and humans, which have the largest brain-to-body weight ratios , to the present day . In 1891, Snell  first described the allometric scaling relationship that emphasizes the dependence of brain size on body size. The most striking observation is that mammals and birds have developed larger brains that are approximately 5–50 times heavier than those of the lower-level vertebrates (e.g., reptiles, fish and amphibians) with similar body mass. It is surprising that mammals and birds developed larger brains, because, brain tissue is extremely demanding in terms of metabolic consumption, because the neuronal electronic signaling that occurs within the brain may have a per-neuron energy cost as high as ten times that of other cells in the body. This difference has attracted much attention to the search for links between brain size, body size and metabolic production. Martin  proposed that brain size is linked to maternal metabolic turnover via a 3/4 allometric scaling law . This work indicated that the total amount of energy available from the body to supply the brain may constrain the size of the brain; however, species with larger brains do not have basal metabolic rates significantly higher than those in species with smaller brains ,,-. There is also no significant difference in the percentage of energy supplied by the body to the brain between endotherms and ectotherms ,. Given these similar metabolic processes and energy supply ratios, why do mammals and birds have larger brains than fish and reptiles of similar weight? How do mammals and birds meet the energy demands of brains that are 5–50 times larger? Although much research has focused on the several-fold differences in the sizes of the brains of primates and those of low-level mammals by considering the improved energy source acquisition styles of primates, such as improvements in food hunting style due to the use of tools, the consumption of cooked food, and differences in metabolic allocation, few studies have focused on the proximate causes of the differences in brain size between lower-level animals (e.g., fish, reptiles and amphibians) and higher-level animals (e.g., primates, mammals and birds). What is the role of temperature and metabolism in promoting or constraining brain size? What is the relative contribution of neuron and glial densities in increasing brain size?
In the present study, we re-examined the relationships between temperature, metabolism, neuronal density, energy cost of individual neurons, brain size and body size across of all the major types of vertebrates. Here we specifically focus on the critical effect of temperature and growth of glia cells in the development of large brain-body size ratio in mammals and birds and origin of allometric body-brain size scaling in vertebrates. We then develop a general model to describe the intrinsic relationship among the examined factors.
Body temperature, metabolism, external temperature and brain size
where exponent α is the allometric slope, C is a constant, and W and P are brain and body weight, respectively. Analyses have shown that C = 0.078 and α = 0.689 for endotherms (including mammals, birds, insectivores, primates, dolphins and humans), and C = 0.014 and α = 0.578 for ectotherms (primarily fish, reptiles and amphibians). The parameters C and α vary across species (see Additional file 1: Table S1). A closer examination of the distributions of body mass versus brain mass reveals that the warm-blooded, endothermic animals with relatively constant body temperatures of approximately 8°C (e.g., mammals, birds, primates and dolphins) form one distinct distribution, and cold-blooded ectothermic animals with body temperatures that vary with the environment and average approximately 16°C (i.e., fish, reptiles and amphibians) form a clear second distribution. Warm-blooded species have brains that are 4–43 times larger than those of ectothermic animals. The fact that the most apparent difference between the two groups is temperature suggests that it is a key factor that correlates with brain size.
If temperature is important, we might predict that cold-blooded species living in disparate environmental temperatures might also have different brain sizes. To examine whether the extrinsic, i.e., environmental, temperature also explains the variation in brain size, we used fish brain and body-size data from locations of different temperatures, obtained from a fish database (http://fishbase.org), and plotted the body-brain mass relationships. The fish and environments examined included the following: 1) 35 fish species living in polar conditions in which the average temperature was ~1°C, 2) 70 fish species living in temperate conditions with an average water temperature of ~15°C, 3) 88 species living in tropical conditions with an average water temperature of 25°C, and 4) 17 shark species living in sub-tropical waters that maintain their body temperatures at 20-30°C via steady contractile activity of muscles , (Additional file 2: Table S2; these data were randomly selected from the fish database). Surprisingly, we found that the fish brain-to-body mass ratio data fell into 3 distinct groups (Figure 1B). Fish living in warm tropical water had brains that were 2–5 times larger than those of the temperate-water fish and 3–15 times larger than those of the fish living in cold polar water. The fit equation for the fish species living in tropical conditions had an allometric slope of 0.7 and a constant of 0.0118 (red line and symbols), the equation for fish living in the temperate waters had an allometric slope of 0.64 and a constant of 0.0078 constant (green line and symbols), and the fish living in the polar waters had the shallowest allometric slope (0.59) and a constant of 0.0036.
Figure 1C directly quantifies the allometric relationship between the environmental temperature (from 1°C to 25°C) of the fish and their average brain mass for two body masses (10 g and 1,000 g). The fit equations indicate that fish brain mass more than doubles for each 10°C increase in temperature. As a comparison, the average mammalian brain sizes in animals weighing 10 g and 1,000 g are plotted in this figure (with a constant temperature of 38°C). This figure shows a nice fit between body mass and brain temperature for three points, but not for the largest brain sizes and highest temperatures. The data from the larger brain sizes/higher temperatures falls above the fit lines, indicating that temperature alone may not be the sole contributor to the development of larger brains. Other factors may contribute to the development of larger brains in mammals.
Together, these data indicate that temperature may be a critical factor in the marked changes in brain size during evolution in different climate conditions. Specifically, for a given body mass, warmer living conditions should result in larger brains.
In addition to this temperature-driven brain enlargement, the difference in brain sizes of endotherms and ectotherms increases as body size increases (Figure 1D). For small body sizes (below 1 gram), the brains of endotherms are atleast 4 times larger than those of ectotherms (black line in Figure 1D). Similarly, tropical-water fish have brains that are at least 3 times larger than those of cold-water fish (dashed line). In contrast to these effects in animals with small body sizes, for animals with body sizes over 100 kilograms, the brains of endotherms are approximately 20 to 40 times larger than those of ectotherms, and tropical-water fish have brains that are more than 10 to 15 times larger than those of cold-water fish. In comparison, the brains of primates are, relatively consistently, 2–3 times larger than those of other mammals, and this difference is less dependent on body size differences (dotted line in Figure 1D).
The emergence of intrinsically constant warm body temperatures together with an increasing brain size, with increasing body mass may be related to a temperature-dependent regulation of body metabolism. It is possible, that changes in body or environmental temperature affects the metabolic rate and consequently affected the evolution of large brains. This effect may depend on body mass.
These analyses suggest that temperature-dependent body metabolism alone cannot explain the differences in brain size among endotherms than among ectotherms. These results also indicate that other factors may play a role in explaining the differences in brain size between warm blooded endothermic animals and cold blooded exothermic animals. It is possible that neural, glial density or the energy demands on these cells are dependent on body temperature.
A general model linking brain and body sizes to metabolism and temperature
where β is close to 1 (here C2 = 0.0052 and β = 1.12 for both rodents and primates) as reported in recent studies ,-, . The numbers of supporting non-neuronal cells in endotherms are proportional to the numbers of neurons and are also strongly correlated with brain mass (Figure 3B). The supporting cells play an important role in providing mechanical and trophic support to neurons. Additionally, data from several ectothermic animals ,- indicate that that C2 = 0.0096 and β = 0.83 (see Additional file 4: Table S4; the numbers of non-neuronal cells are not available for ectotherms).
where , α = βγ + βξ, and , called effective temperature. Equation (7) links body temperature, body mass, brain mass and neuron metabolic rate (Mneuron), provides a general theoretical framework for quantifying changes in brain size during evolution, and provides an origin of the formula of Eq. (1) that was derived from experimental data. The temperature range used for Eq. (7) is 0 ~ 42°C, corresponds to what is normally observed in polar fish to the body temperature of birds. The equations are not valid for temperatures above or below these values, because all the scaling parameters have been derived from animal data acquired within this temperature range.
Equation (7) links brain mass with the metabolic consumption rate of individual neurons (Mneuron). Recent studies suggest that the energy cost per neuron (Mneuron) in the brain is stable and nearly invariant across mammal species . Calculations based on the available data revealed that Mneuron is, on average, 2.51 × 10−10 watts for endotherms and 0.563 × 10−10 watts for ectotherms (see Figure 4C and Additional file 5: Table S5).
Note that model predictions for endothermic brain sizes are generally 2–5 times lower than actual brain masses of primates and dolphins, suggesting there other evolutionary factors mat contribute to the larger brain size in these species, as has been indicated in recent reports ,,. The model in the present study does not make any attempt to capture these effects.
The model predictions for tropical-water fish, temperate-water fish, and cold-water fish are shown in Figure 5B, which predicts that brain size at 25°C should be 6-fold higher than that in fish at 1°C and that at 15°C brain size should be 3-fold higher than at 1°C. The model used actual data-derived parameters of C1 = 0.00051, γ = 0.879, C2 = 0.0096, β = 0.83, C3 = 0.092 and ζ = −0.102, which for fish results in the equation based on Eq. (7). Note, data for fish brain, glial density data are currently not available, so the fitting is imperfect, and only includes the temperature- related differences.
The model prediction for insectivores (with body temperatures of approximately 31°C) is perfectly aligned with the actual data with predicted parameters of λ = 0.0409 and α = 0.6608 (CC = 0.952, adjusted- R2 = 0.91, MSE = 0.0211, p < 1×10−5). Figure 5D quantifies the allometric relationship between the temperatures that fish live at, and their average brain mass for two body masses (10 g and 1,000 g). The equations for the fish were given by and for mammals were given by . At a given body weight, as temperature increases, brain mass of fish increases, but the increase of brain mass with temperature is larger in mammals. This relationship is well captured by the model predictions (see the black line in Figure 5D), with multiple linear regression analysis -- here temperature T is the regressor variable -- between log10 (actual brain mass) and log10(model prediction) for 10 g: CC = 0.998, adjusted- R2 = 0.995, MSE = 0.0041, p < 0.0023; and for 1000 g: CC = 0.9999, adjusted- R2 = 0.9998, MSE = 0.0049, p < 0.0001.
For most of animal species (i.e., temperate and tropic fishes, reptiles, amphibians, insectivores, mammals and birds), model predictions matched real brain data well, with CC > 0.95, MSE = 0.07, p < 10−5) with ratios of (model prediction)/(actual brain mass) close to 1 (Figure 7B) while there are larger mean square errors for primates (MSE = 0.23, CC = 0.956) and dolphins (MSE = 0.544, CC = 0.97), and dinosaurs (MSE = 0.51, CC = 0.803) with ratios of (model prediction)/(actual brain mass) either much less or much more than 1 (Figure 7B). The regression analysis gives CC = 0.965, adjusted- R2 = 0.932, MSE = 0.089, p < 1 × 10−5 for archiac mammals, and CC = 0.97, adjusted- R2 = 0.94, MSE = 0.0162, p < 1 × 10−3 for mesozoic mammals.
The predictions of the model could be improved by more accurate measurements of the body temperature, body metabolism, neuronal metabolism and neuronal/glial densities of each group of species.
Discussion and conclusion
There is increased interest in examining the key factors facilitating enlargement of the brain during evolution. Given that the energy cost of the brain’s neurons is more than ten times that of the cells of the body, the factors that regulate the brain’s energy supply and energy cost should be given thorough consideration. In this study, we re-examined data on brain size, body size and metabolic rates for all the major types of vertebrates, developed a theoretical framework based on examination of the real data, and identified several critical factors that may trigger the dramatic enlargement of the brains of birds and mammals as compared with fish, reptiles and amphibians. The most critical factor was temperature. When the endothermic animals evolved from ectothermic animals, two unique features were bound together in endotherms: larger brains and higher body temperatures (on average, 20°C higher than those of ectothermic animals). The warm temperature was critical in speeding the biochemical processes and making marked metabolic differences. Our analysis revealed that in small animals the basal metabolic rate of endotherms is 60 times greater than that of ectotherms, and in large animals it is ~ 10 times greate (Figure 2C). However, the brain sizes of small endotherms are only approximately 4 times greater than that of small ectotherms but the brains of large endotherms are more than 40 times greater than the brains of large ectotherms. Clearly, in large animals, the same basal metabolic rate of endothermic animals should support larger brain tissue in ectothermic animals, than it actually does (Figure 2D), suggesting that temperature was only one of the key factors in mediating the enlargement of the brains of endotherms. Note a similar analysis published recently points out that temperature correlates with brain size .
Other factors included in our analysis are brain metabolism and number of supporting glial neurons. Analysis of the brain metabolism data showed that that the average metabolic cost of individual neurons in ectothermic brains is ~ 5.63 × 10−11 watts, which is nearly 5 times lower than the average metabolic cost of endothermic brains (Figure 4C). The lower energy cost of individual neurons could be attributed to the effect of colder temperature on metabolism and the occurrence of fewer synapses in ectothermic brains , or the lower energy cost of individual neurons could be associated to the smaller number of glia in ectotherms ,,. Glia are the major non-neuronal supporting cells that maintain homeostasis, form myelin, and provide mechanical and tropic support to neurons. In the vertebrate CNS, most glia originate from portions of the developing neural tube—the exception being olfactory ensheathing glia —and the energy cost of glia is generally only a few percent of that of neurons ,. Recent data suggest that the evolution of the nervous system was accompanied by increases in the number and size of glia ,,. In vertebrates, the glia-to-neuron ratio in the cortex increases with the size of the brain ,. Figure 3 and Eq. (3) show that brain mass increases much faster in endothermic brains than in ectothermic brains as the number of neurons increase, which is also suggestive of increases in the numbers of non-neuronal supporting cells. Glia contribute to the faster propagation of nerve signals and long-range communications, particularly via the evolution of myelinating glia in developed endotherms . These energetically inexpensive glial cells surround neurons and occupy a relatively large portion of the brain , while also providing energy support to neurons and aiding efficient communication between cortical areas ,. Thus, these cells may be one of the critical factors that promoted brain enlargement.
The evolution of the large brains of endotherms is associated with multiple factors. To quantify the contribution of each factor to the brains of mammals and birds that are tens of times larger than those of fish, reptiles and amphibians, we built up a general theoretical model to examine the origin of body-brain size allometric scaling relationship by linking the key factors of temperature-dependent metabolism, neuron energetics, neuronal density and body size. This basic framework suggests that temperature and the development of supporting non-neuronal cells may have been the critical factors that correlated with, or might even be causal, for the enlargement of the brains of endotherms (Figure 5A). This framework also predicts that the brains of cold-blooded animals living in warmer conditions should be several times larger than those of cold-blooded animals that live in colder conditions. This prediction was confirmed by the analysis of the brain sizes of fish living in various temperatures (Figures 1B and 5B). Indeed, owing to the absence of measurements of neuronal density (and glia-to-neuron ratios) for the brains of fish that live in different temperatures, the model prediction in Figure 5B did not capture the differences in the slopes between the tropical and polar fish that are shown in Figure 1B and D. However, a prediction from the endothermic brain would be that tropical fishes have larger numbers of glia in their brains than do the fish that live in cold conditions. These predictions can be tested by experimental investigations.
No new animal/human data was generated in this study. All the data used in this study are from references and online database.
Animal data sources
The brain and body size datasets for the endothermic and ectothermic animals (Figure 1A) are from references ,,, and are listed in Additional file 1: Table S1. The body and brain size datasets for fish that live in different temperatures and were used to create Figure 1B were collected from the database at www.fishbase.org and are listed in Additional file 2: Table S2. The metabolism-to-body scaling relationships of the endothermic and ectothermic animals were collected from published papers ,- that are listed in Additional file 3: Table S3 and are plotted in Figure 2. The data regarding the allometric scaling of the brain mass and total neuronal numbers for the endothermic and ectothermic animals were collected from published papers , and are listed in Additional file 4: Table S4 and plotted in Figure 3. The datasets for the ratios of brain metabolism to resting body metabolism are listed in Additional file 5: Table S5, are plotted in Figure 4 and were collected from published papers .
YY conducted research, analysed the data, built up the mathematical model, worte the paper. JK helped mathematical model corrections, RS helped write the paper and result discussion, JF helped data statistical method. All authors reviewed the manuscript.
We thank Harry J. Jerison for sharing the brain-body mass data. We express our deep gratitude to Fahmeed Hyder, Gordon M Shepherd, Michael Hines, and David Waxman for valuable discussions and comments. This project was funded by the National Natural Science Foundation of China (31271170) and was also supported by the program for the Professor of Special Appointment (Eastern Scholar SHH1140004) at Shanghai Institutions of Higher Learning.
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